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Федеральный научно-клинический центр реаниматологии и реабилитологии

Госпитализация в ФНКЦ РР 8 495-139-98-13 Санаторий "Узкое" 8 495-427-90-66 НИИ ОР им.В.А.Неговского 8 495-694-27-08 Платные медицинские услуги 8 495-139-98-40

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Федеральный научно-клинический центр реаниматологии и реабилитологии

Госпитализация в ФНКЦ РР 8 495-139-98-13 Санаторий "Узкое" 8 495-427-90-66 НИИ ОР им.В.А.Неговского 8 495-694-27-08 Платные медицинские услуги 8 495-139-98-40

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Писарев Владимир Митрофанович
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Писарев Владимир Митрофанович
Писарев
Vladimir M. Pisarev Professor (Genetics), MD, PhD, DSc (Immunology/Allergology & Genetics). Head, Laboratory of molecular mechanisms of critical illness, V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, Russia; 107031, 25 Petrovka Bldg. 2. ; . Addtl. appointments: 2011– current: Lead Scientist, Laboratory of Health Care Associated Infections (HAI), Central Research Institute of Epidemiology, Rospotrebnadzor, Moscow, Russia; 2012– current: Lead Scientist, Laboratory of Infection Immunology, Dmitry Rogachev Research Center for Pediatric Hematology, Oncology and Immunology, Ministry of Public Health, Moscow. Education and Training:  1969-1975 student, I.M. Sechenov First Moscow Medical Institute, Moscow, Russia  1975 MD (Epidemiology, Hygiene and Sanitation).  1975-1980 Trainee in Genetics/Immunogenetics and PhD student, Institute of Medical Genetics, USSR Academy of Medical Sciences, Moscow, Russia  1981 Candidate of Medical Sciences (PhD), Genetics, Institute of Medical Genetics, USSR Academy of Medical Sciences, Moscow, Russia  1995 Doctor of Medical Sciences (DSc), Allergology and Immunology & Genetics, Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia.  1995-1998 Visiting Scientist/Trainee, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USA  2014, 2 months : visiting scholar, Laboratory of Immunology (Prof. D. Gabrilovich), Wistar Institute, Philadelphia, PA, USA  2016, 1 month: visiting scholar, Laboratory of Immunology (Prof. D. Gabrilovich), Wistar Institute, Philadelphia, PA, USA Professional Experience: 1981 – 1995: junior, senior and leading Scientist, Laboratory of Immunogenetics, Institute of Medical Genetics/ Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia; 1995-1998: Visiting Scientist/Trainee, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USA; 1998-2009: University of Nebraska Medical Center (UNMC), Omaha, NE, USA (Department of Pathology and Microbiology; Eppley Institute for Research in Cancer and Allied Diseases; Department of Surgery, College of Medicine): Research Assistant Professor (since 2009 - Adjunct Assistant Professor); 2010 – 2011: Lead Scientist, Laboratory of stem cells genetics, Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia; 2012-current: Head, laboratory of molecular mechanisms of critical illness, V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, Russia Current scientific research topics of interest: Mechanisms of regulation of immune responses in human pathology (myeloid-derived suppressor cells in critical illness and cancer); genetic and molecular predictors in critical illness for personalization/ precise medicine including health care associated infections; genomics and immunomics in sepsis/septic patients suffering from health care associated infections; immune mechanisms in critical care post-neuroreanimation; linking the bacterial multidrug resistance/antibiotic tolerance and innate immunity in health care associated infections. Previous contribution: Studies of antigen-specific T cell mediated immunosuppression (1975-1981); developoing and eva;uaqting the mechanisms of action of peptide and nucleoside analogue immunomodulatory agents (1981-1995); developing the extracorporeal immunopharmacotherapeutic approaches to treatment of immunodeficiencies (1988-1995); developing peptide-based, dendritic cell-based and genetic vaccines (HIV, MUC1, p53, survivin) and polymer-based immune adjuvants against cancer (1995-2007), developing the epitope peptides for T-cell immune responses induction and evaluation (2006-2009); studies of myeloid derived suppressor cells in cancer (2003-2013) and sepsis/septic shock patients (2014-current); linking the innate immune system and dormant forms of bacteria causing health care-associated infection in critical care medicine (2015-current); role of allelic polymorphism (NRF2, AQP5, TLR9 etc.) in health care-associated infections (2016-current). Teaching Experience: Dissertation supervisor and consultant: 1987-1995, five PhD students in different fields of experimental medicine (immunology, immunopharmacology, genetics, anesthesiology & reanumatology); 2009-2011: consultant of doctoral studentship - DSc Thesis in Pharmacology; 2017-current: supervisor of three 3 PhD students (Anestesiology-Reanimatology; Pathophysiology; Genetics). Training of students/residents: 2004-2007, training of the College of Medicine’ summer students and pre-doctoral students in Cancer Immunoinformatics, ELISA and ELISPOT, Tumor Immunology (Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE, USA); 2007-2009, training the residents of Department of Surgery, College of Medicine, UNMC, in quantitative imaging analysis and immunohistology (UNMC). Lectures: 2012-2017, lectures for critical care physicians. Scientific Expert functions: 2003-2007: U.S. Civilian Research and Development Foundation (CRDF), reviewer.2008-2010: Scientific Panel Reviewer (prostate cancer) for Congressionally Directed Medical Research program (CDMRP), USA.2010 - current: scientific expert (reviewer of grant proposals) of Russian Academy of Sciences; scientific expert of Russian Foundation for Basic Research; scientific expert for Ministry of Education and Science, Russia; reviewer for Journal of Immunology, European Journal of Immunology, Cancer Research, Journal of Leukocyte Biology, Obschaya Reanimatologiya (General Reanimatology), Medicinskaya Genetika (Medical Genetics); 2010 - current: Member, Dissertation Council of the Research Center for Medical Genetics Moscow, Russia (Genetics); 2012 – current: Member, Dissertation Council of the V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation (Reanimatology & Anestesiology; Pathophysiology); 2012- current: Management of the Laboratory of molecular mechanisms of critical illness; 2014-current: General Secretary, Society for Shock Studies (Russia) - SSSR, a member of International Federation for Shock Studies; 2012 – current: Member, Dissertation Council of the V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation (Reanimatology & Anestesiology; Pathophysiology); Member, editorial board, and Scientific Editor (English version) of scientific and practical medical journal : "Obshaya Reanimatologiia" General Reanimatology, Scopus journal). Other professional activities: 2007-2009 Scientific Reviewer (in cancer) for Congressionally Directed Medical Research program, CDMRP, USA; 2010 - current: expert (reviewer of grant proposal) of Russian Academy of Sciences , expert for Russian Foundation for Basic Research, expert for Ministry of Education and Science; reviewer for Journal of Immunology, European Journal of Immunology, Cancer Research, Journal of Leukocyte Biology (2015-2017). Scientific activities: More than 160 scientific publications in immunology, infection diseases, and critical care issues have been published including 2 monographs (2003 and 2012) and numerous highly cited publications in peer-reviewed journals (Nature Medicine, Cancer Research, Clinical Cancer Research, Int. J. Cancer, Stem cells, Molecular Pharmacology, Vaccine, Journal of Immunotherapy, J. Clin. Investigation, Biomaterials, PlosOne etc.), two patents. Hirsch index 16 (Web of Science), >1250 citations without self-citations (Web of Science). Most recent research grant – from RFBR, 2016-2017, principal investigator (PI). Currently - PI in two projects in genetics and immunology of critical care illness financially supported by Federal Agency of Scientific Organizations, Russia. Vladimir M. Pisarev. Selected publications (2007-2018) Extracted from >160 publications 1. Srinivas Nagaraj, Vladimir Pisarev, Leo Kinarsky, Simon Sherman, Carlos Muro-Cacho, Dario Altieri and Dmitry Gabrilovich (2007). Dendritic Cell-based Full-length Survivin Vaccine in treatment of experimental tumors. Journal of Immunotherapy. 30(2):169-179. 2. Srinivas Nagaraj, Kapil Gupta, Vladimir Pisarev, Leo Kinarsky, Simon Sherman, Loveleen Kang, Donna Herber, Jonathan Schneck, and Dmitry Gabrilovich (2007). Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer. Nature Medicine. 13 (7): 828-835 3. Eric Benner, Rebecca Banerjee, Ashley Reynolds, Simon Sherman, Vladimir M. Pisarev, Vladislav Tsiperson, Craig Nemachek, Pawel Ciborowski, Serge Prsedborski, R. Lee Mosley, and Howard E. Ghendelman. Nitrated alpha-Synuclein Adaptive Immunity Induces Dopaminergic Neuronal Degeneration in a Murine Model of Parkinson’s Disease (2008). PLoS ONE, 3(1): e1376. 4. Ninkovic T, Kinarsky L, Engelmann K, Pisarev V, Sherman S, Finn OJ, Hanisch FG. Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) epitopes (2009). Mol Immunol. 47(1):131-40 5. Gaymalov ZZ, Yang Z, Pisarev VM, Alakhov VY, Kabanov AV. The effect of the nonionic block copolymer pluronic P85 on gene expression in mouse muscle and antigen-presenting cells. Biomaterials (2009): 30(6): 1232-45. Dali Huang, George P. Casale, Jun Tian, Subodh M. Lele, Vladimir M. Pisarev, Melanie Simpson, and George P. Hemstreet III. UDP-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer (2010). Int. J. Cancer 126(2):315-27. 6. Tangying Lu, Rupal Rampakrishnan, Soner Altiok, Pingyan Cheng, Esteban Celis, Vladimir Pisarev, Simon Sherman, Michael Sporn, Dmitry Gabrilovich. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice (2011). Journal of Clinical Investigation 121, 10:4015-4029.IF 14,150 (JCR). 7. Hemstreet GP 3rd, Rossi GR, Pisarev VM, Enke CA, Helfner L, Hauke RJ, Tennant L, Ramsey WJ, Vahanian NN, Link CJ. Cellular immunotherapy study of prostate cancer patients and resulting IgG responses to peptide epitopes predicted from prostate tumor-associated autoantigens.J. Immunother. 2013 Jan;36(1):57-65. doi: 10.1097/CJI.0b013e3182780abc. 8. Svetlana Bunimovich-Mendrazitsky, Vladimir Pisarev, Eugene Kashdan. Modeling and simulation of low-grade urinary bladder carcinoma. Comput Biol Med. 2015; 58C: 118-129. 9. Pisarev VM, Gaponov MA, Tutelyan AV, Grebenchikov OA, Chumachenko AG, Myazin AE, Khaidukov SV, Gaponov AM. NRF2 genetic polymorphism and accumulation of oxidized low-density lipoproteins are drivers or biomarkers of heterogeneity of circulating regulatory myeloid cells subsets, M-MDSC and G-MDSC, in severe sepsis and septic shock. Infection, 2015, 43: 24-25. ISSN 0300-8126. DOI 10.1007/s15010-015-0827-1. 10. Tutelyan AV, Gaponov AM, Pisarev VM, El-Registan GI. [Microbial dormancy and prevention of healthcare-associated infections].Ter Arkh. 2015;87(11):103-108. doi: 10.17116/terarkh20158711103-109. 11. Demkina EV, Loiko NG, Mulyukin AL, Smirnova TA, Gaponov AM, Pisarev VM, Tutel'yan AV, Nikolaev YA, El'-Registan GI. [Effect of Inherent Immunity Factors of Development of Antibiotic Tolerance and Survival of Bacterial Populations under Antibiotic Attack].Mikrobiologiia. 2015 Nov-Dec;84(6):660-72 12. Chumachenko, A.G., Myazin, A.E., Kuzovlev, A.N., (...), Golubev, A.M., Pisarev, V.M.* Allelic variants of NRF2 and TLR9 genes in critical illness. Obshchaya Reanimatologiya , 2016,v.12,No.4,pp.8-23. 13. Myazin, A.E., Chumachenko, A.G., Kuzovlev, A.N.,(…) Golubev, M.A., Pisarev, V.M*. Genetic variants of intron region of aquaporin AQP5 gene and development of pulmonary edema in lung infection complicated by septic shock. Obshchaya Reanimatologiya 2016, v.12,No.3, pp. 16-31. 14. Tutelyan, A.V., Pisarev, V.M., Minaeva, N.Z., (...), Gracheva, A.N., Solopova, G.G. Generation of antibiotic tolerant bacterial persisters in immunocompromized patients with hematologic and malignant diseases: a new problem of health-care associated infections Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2016, v.71, No.3, pp.183-189. 15. A. N. Kuzovlev,. V. V. Moroz, A. M. Goloubev, V.M. Pisarev, E.A. Tishkov. New novel biomarkers of alveolar damage in ARDS in septic shock patients. SHOCK, 2016, v.46, No. 4 (S2),p. 29. 16. Morozov, A.S., Bessonov, I.V., Nuzhdina, A.V., Pisarev, V.M. Sorbents for extracorporeal removal of toxic substances and molecules with adverse biological activity (Review) Obshchaya Reanimatologiya 2016, v.12,No.6, pp.82-107. 17. Kopitsyna M.N., Morozov, A.S., Bessonov, I.V., Pisarev, V.M. Lobakova E.C., Bukharin O.V.Ligands for selective elimination of bacterial endotoxins of gram-negative bacteria.Jurnal Microbiologii,epidemiologii, 2017,No.3, pp.115-126. 18. Kuzovlev A., Moroz V., Myazin A., Chumachenko A., Pisarev V. GENETIC VARIANTS OF INTRON REGION OF AQUAPORIN AQP5 GENE AND DEVELOPMENT OF PULMONARY EDEMA IN LUNG INFECTION COMPLICATED BY SEPTIC SHOCK. Critical Care. 2017. Т. 21. № S1. С. 5-6. 19. V.M. Pisarev, A.M. Gaponov , A.V.Tutelyan, A. Semchenkova, A. M. Popov, A.G. Chumachenko, A.E. Myazin, O.A. Grebenchikov, V.V. Likhvantcev, T.S. Zabelina, I.N. Tyurin, R. Cherpakov. Myeloid-derived suppressor cell subsets in sepsis patients and in in vitro bacterial microenvironment model. Programme and Abstract Book. 17th Congress of the European Shock Society. Institute Pasteur, France, September 13-15, 2017. Стр. 116. www.essparis2017.org. 20. A Kuzovlev, V. Moroz, A. Goloubev, A. Myazin, A. Chumachenko, V. Pisarev. Genetic variants of intron region of aquaporin AQP5 gene and development of pulmonary edema in lung infection complicated by septic shock.development. Critical Care 2017, 21(S.1):58 (P359), pp. 5-6. DOI: 10.1186/s13054-017-1629-x. 21. L. N. Porokhovnik, and V. M. Pisarev. Association of Polymorphisms in NFE2L2 Gene Encoding Transcription Factor Nrf2 with Multifactorial Diseases. Russian Journal of Genetics, 2017, Vol. 53, No. 8, pp. 851–864. © Pleiades Publishing, Inc., 2017. ISSN 1022-7954 22. Kopitsyna M.N., Morozov, A.S., Bessonov, I.V. Pisarev, V.M. Methods for detection of bacterial endotoxin in critical care medicine . Obshaya Reanimatologiya, 2017,v.13, No.5, pp.109-120. ISSN 2411-7110. DOI:10.15360/1813-9779-2017-5-109-120. 23. Svetlana V. Kostyuk, Lev Porokhovnik, Elizaveta Ershova, E. M. Malinovskaya, Marina Konkova, L. V. Kameneva, O. A. Dolgikh, V. P. Veiko, Vladimir M. Pisarev, Andrew V. Martynov, Vasilina Sergeeva, A. A. Kalyanov, Anton D. Filev, Julia M. Chudakova, Margarita S. Abramova, Sergei Kutsev, Vera L. Izevskaya and Natalia Veiko "Changes of KEAP1/NRF2 and IKB/NF-kB expression levels induced by cell-free DNA in different cell types". Oxidative Medicine and Cellular Longevity (2018). In Press. Research Article 1052413. IF=4,593 (JCR)
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